AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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STUDIA CHEMIA - Ediţia nr.2, Tom II din 2019 | |||||||
Articol: |
A PREDICTIVE TOXICITY STUDY OF PEIs, PAMAM AND ZAC DENDRIMERS. Autori: CLAUDIU N. LUNGU, CSABA PAIZS, MELINDA E. FÜSTÖS, ANAMARIA ORZA, MIRCEA V. DIUDEA, IRENEUSZ P. GRUDZINSKI. |
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Rezumat: Polyethyleneimines (PEIs) and polyamidoamine dendrimers (PAMAM) are widely used as non-biological transporters in modern gene therapies. In this study, several zero-generation aromatic core ZAC dendrimers were computationally studied for predictive toxicity assessment. The chemical synthesis of the ZAC dendrimers was carried out using three different bromomethylbenzene derivatives as aromatic core and dialkanolamines as branching units with different carbon chain length. Quantitative structure-activity relationships (QSAR) and virtual high throughput toxicity screening (vHTTS) assays were applied on the synthesized zero generation dendrimers to evaluate their toxicities. Keywords: molecular descriptors, pharmacophore, QSAR, continuous structures, toxicity, maximum recommended daily dose, dendrimers. |
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